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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
25.76
Human Site:
S226
Identified Species:
37.78
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S226
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S226
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
E298
Y
K
E
L
Q
K
S
E
K
L
D
E
Q
R
A
Dog
Lupus familis
XP_853397
405
45606
S227
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
S217
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
Rat
Rattus norvegicus
P59241
397
44856
S219
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
A133
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
Chicken
Gallus gallus
XP_425725
409
46456
P228
Y
L
I
L
E
Y
A
P
R
G
E
V
F
K
E
Frog
Xenopus laevis
Q91819
408
46443
T233
F
R
E
L
Q
K
C
T
R
F
D
D
Q
R
S
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
D150
Q
R
Y
G
R
F
D
D
Q
R
T
A
T
Y
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
Y158
D
E
P
R
S
A
K
Y
T
Y
Q
V
A
N
A
Honey Bee
Apis mellifera
XP_395732
327
37711
P157
F
K
E
L
N
A
Q
P
E
K
R
F
D
E
I
Nematode Worm
Caenorhab. elegans
O01427
305
34731
Y135
P
T
A
A
K
Y
M
Y
E
I
A
D
A
L
S
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
T108
G
R
F
D
E
Q
R
T
A
S
Y
I
S
Q
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
K112
Y
K
E
L
Q
K
C
K
Y
F
S
E
R
R
A
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
G197
Y
K
L
L
R
L
H
G
P
F
N
D
I
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
66.6
100
N.A.
100
100
N.A.
6.6
13.3
60
6.6
N.A.
0
13.3
0
6.6
P-Site Similarity:
100
100
73.3
100
N.A.
100
100
N.A.
40
40
93.3
20
N.A.
6.6
33.3
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
0
13
7
7
7
0
7
7
13
0
32
% A
% Cys:
0
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
7
0
0
7
7
0
0
44
19
7
0
0
% D
% Glu:
0
7
57
7
13
0
0
7
13
0
7
44
7
7
7
% E
% Phe:
13
7
7
0
0
7
0
0
0
50
0
7
7
0
0
% F
% Gly:
7
0
0
7
0
0
0
7
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
0
7
7
7
7
0
7
% I
% Lys:
7
25
0
0
7
50
7
7
38
7
0
0
0
7
0
% K
% Leu:
0
7
7
69
0
7
32
0
0
7
0
0
0
19
7
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
7
0
0
0
0
0
7
0
0
7
0
% N
% Pro:
7
0
7
0
0
0
0
13
7
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
57
7
7
0
7
0
7
0
44
7
0
% Q
% Arg:
0
50
0
7
13
7
7
0
13
7
7
0
7
50
0
% R
% Ser:
0
0
0
0
7
0
7
32
0
7
7
0
7
0
13
% S
% Thr:
0
7
0
0
0
0
7
13
13
0
7
7
7
0
32
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
57
0
7
0
0
13
0
13
7
13
7
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _